Structural Determinants of Isoform Selectivity in PI3K Inhibitors
نویسندگان
چکیده
منابع مشابه
Structural selectivity of human SGLT inhibitors.
Human Na(+)-D-glucose cotransporter (hSGLT) inhibitors constitute the newest class of diabetes drugs, blocking up to 50% of renal glucose reabsorption in vivo. These drugs have potential for widespread use in the diabetes epidemic, but how they work at a molecular level is poorly understood. Here, we use electrophysiological methods to assess how they block Na(+)-D-glucose cotransporter SGLT1 a...
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ژورنال
عنوان ژورنال: Biomolecules
سال: 2019
ISSN: 2218-273X
DOI: 10.3390/biom9030082